Does Obesity have an Impact on Sperm Quality and Quantity?

 The study cohort, which consisted of men who visited an infertility clinic for treatment between January and December 2016, had an average age of 35 years. A total of 201 people (16%) were overweight. Using World Health Organization norms, the researchers classified spermatozoa as progressive, no progressive, or immotile (WHO). The researchers claim that CASA allows them to examine more sperm parameters with greater overall reliability than traditional microscopy approaches. Obesity is also linked to categorical outcomes of male infertility, such as oligospermia and asthenospermia. The data reveal that after adjusting for age, smoking status, and diabetes mellitus, the relationships between obesity and numerous sperm parameters remained consistent.

"The findings from our current data set imply that for couples seeking infertility therapy, efforts focusing on male weight loss before to conception are recommended," the authors say. Although a link between obesity and sperm abnormalities has long been suspected, previous research findings have been mixed and inconclusive. Some studies found negative associations between obesity and sperm count, concentration, motility, and the number of normal morphological forms, while others found no link. "Previous null findings between obesity and sperm-quality indicators may be attributable to inability to account for potential confounders," the researchers speculate, adding that more study is needed to confirm their findings.

"Obesity's impact on sperm quality has piqued researchers' curiosity, and there is ample literature on the processes by which obesity degrades sperm function. However, there is no unanimity on how obesity affects individual sperm parameters." Prior research on the link between obesity and fertility has found that paternal obesity before conception can harm the embryo's health as well as negatively effect implantation, pregnancy, and live birth rates. According to the study authors, new findings from epigenetic research reveal that male obesity can influence future child fertility. The investigators further highlight that after weight loss, whether by diet and exercise or bariatric surgery, adjusted testosterone and oestrogen ratios, as well as higher levels of plasma sex hormone-binding globulin (SHBG), have been recorded. In the children of obese fathers who lost weight, normalized sperm microRNA profiles and metabolic syndrome were found, as well as improvements in sperm concentration and motility following weight loss and vitamin C treatment.

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